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1. TPMT testing is crucial — Perform before initiation if accessible; prevents potentially fatal myelosuppression in deficient patients. 2. Febuxosta...
1. Mandatory TB screening — Latent TB reactivation can be fatal; always perform Mantoux/IGRA and chest Xray before initiation; treat latent TB for at ...
1. Triple therapy mandatory in transplant — Always combine with calcineurin inhibitor (ciclosporin or tacrolimus) and corticosteroid for transplant pr...
Not interchangeable with MMF: Mycophenolate sodium 720 mg provides equivalent mycophenolic acid exposure to mycophenolate mofetil 1000 mg — direct mgt...
Therapeutic drug monitoring is mandatory — sirolimus has narrow therapeutic index and significant interpatient variability in pharmacokinetics; use LC...