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PCIspecific agent: Only effective when PCI is performed; not useful in conservative medical management of ACS Readministration caution: Avoid repeat...
Start after abstinence is achieved: Unlike disulfiram, acamprosate does not cause a reaction with alcohol, but efficacy is best when started promptly ...
Acarbose is most effective for isolated postprandial hyperglycaemia — not useful for fasting glucose correction; consider for patients with predominan...
Acebrophylline is not a firstline bronchodilator — reserve for addon therapy in COPD/chronic bronchitis with mucus hypersecretion Mucoregulatory ben...
1. ISA advantage: Acebutolol causes less resting bradycardia and fatigue than betablockers without ISA — consider in patients who experience excessive...
1. GI risk assessment essential: Always evaluate GI bleeding history and consider prophylactic PPI in highrisk patients (elderly, prior ulcer, concurr...
1. Paraesthesias are expected — tingling of extremities and lips is a common, harmless effect; reassure patients that this indicates drug activity and...
IV route is preferred for paracetamol poisoning — oral NAC has high emesis rate and erratic absorption after overdose; reserve oral for settings witho...
Pregnancy prevention is paramount — counsel all women of reproductive age extensively; document contraception counselling Absolute alcohol avoidance...
1. Timing is critical — acyclovir efficacy is maximized when started within 72 hours of rash onset for zoster, 24 hours for varicella, and as early as...
Mandatory TB screening (IGRA or Mantoux + Chest Xray) before initiation is nonnegotiable — India has high TB prevalence; treat latent TB for at least ...
Administration technique critical: Administer as rapid IV push (1–2 seconds) through largebore IV in antecubital fossa, immediately followed by ≥20 mL...
Mandatory hepatic monitoring is unique among antidepressants — ensure patient understands and complies with LFT schedule; document informed consent re...
1. National Deworming Day (NDD): Standard dose is 400 mg for children >2 years; 200 mg for 1–2 years. Held biannually on February 10 and August 10. 2...
Weekly dosing (70 mg once weekly) provides equivalent efficacy to daily dosing with significantly better adherence — preferred regimen for most patien...
1. Preferred in CKD: Unlike cholecalciferol, alfacalcidol does not require renal 1αhydroxylation — preferred choice in CKD stages 3–5 and dialysis pat...
Preferred αblocker in men with BPH who experience orthostatic intolerance with tamsulosin or silodosin Lower incidence of ejaculatory dysfunction co...
Reserve aliskiren for patients intolerant to ACE inhibitors (e.g., persistent dry cough) or ARBs, as cardiovascular outcome data are less robust Nev...
Prefer 30 mg daily as initial dose for optimal efficacy — reduce to 10 mg only if adverse effects are doselimiting Structured contraception counsell...
Never initiate during acute gout — can prolong or worsen the flare; wait until attack fully resolves Start low, go slow — begin with lowest dose and...
1. Weight neutrality: Alogliptin does not cause weight gain, making it suitable for overweight/obese T2DM patients who cannot tolerate SGLT2 inhibitor...
1. Not firstline for chronic anxiety — SSRIs (escitalopram, sertraline) are preferred for longterm anxiety management; reserve alprazolam for shortter...
Use aluminiumcontaining antacids for quick symptomatic relief only; not suitable for maintenance therapy in GERD or peptic ulcer disease Always scre...