RxIndia
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1. Timing is critical — acyclovir efficacy is maximized when started within 72 hours of rash onset for zoster, 24 hours for varicella, and as early as...
1. Never use without a pharmacokinetic booster: Darunavir alone has poor bioavailability — always coadminister with ritonavir (preferred) or cobicista...
Always check HIV status before initiating — entecavir monotherapy in undiagnosed HIVHBV coinfection can select for HIV resistance (M184V); use tenofov...
Always calculate realtime creatinine clearance before each ganciclovir dose — renal function directly determines dosing Neutropenia is the doselimit...
Lamivudine is well tolerated and forms the backbone of many firstline ART regimens in India Low genetic barrier to resistance — never use as monothe...
Timing is critical: Most effective when started within 48 hours of symptom onset; however, hospitalised patients and highrisk individuals may benefit ...
Adherence consideration: Twicedaily dosing may reduce longterm adherence; switch to oncedaily 1,200 mg regimen in eligible virologically suppressed pa...
1. Primarily a booster, not an active agent: Ritonavir at 100 mg is used almost exclusively as a pharmacokinetic enhancer for other PIs — full antivir...
Never use sofosbuvir as monotherapy — always combine with appropriate DAA partner based on genotype and clinical scenario Mandatory HBV screening be...
1. NACO firstline backbone: TDF + Lamivudine + Dolutegravir is the preferred firstline ART regimen in India for treatmentnaïve adults and adolescents,...
Valganciclovir provides bioavailability equivalent to IV ganciclovir (~60% converted to ganciclovir) — allows outpatient management and early hospital...