RxIndia
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1. Dosedependent action: Lower doses (50–300 mg/day) preferentially block presynaptic D2/D3 autoreceptors, enhancing dopamine transmission and targeti...
Unique dopamine partial agonist mechanism — provides antipsychotic effect while causing less hyperprolactinaemia and potentially less negative symptom...
1. Sublingual technique is critical — ensure patient understands that tablet must dissolve under tongue; swallowing dramatically reduces absorption an...
D3preferring pharmacology — cariprazine has highest D3:D2 binding ratio among available antipsychotics; theoretically beneficial for negative symptoms...
High sedation profile: Chlorpromazine is one of the most sedating antipsychotics — useful for acute agitation but limits longterm tolerability; consid...
1. Start low, go slow: Initiate at 12.5 mg and titrate gradually to minimise hypotension, sedation, and seizure risk — rapid titration increases adver...
1. Dual utility: Lowdose flupentixol (0.5–1 mg/day) is widely used in India for depression with anxiety — this is distinct from its antipsychotic use ...
Depot is for maintenance, not acute episodes: Fluphenazine decanoate is intended for chronic maintenance therapy in stable patients — NOT for acute ps...
Always confirm oral tolerability before initiating depot formulation Correct hypokalaemia and hypomagnesaemia before administering parenteral halope...
1. Mandatory slow titration: Always initiate with 1 mg BD and titrate over minimum 4 days to prevent severe orthostatic hypotension — do not skip titr...
Weight gain is most pronounced in first 6 months; early dietary counselling and exercise recommendations are essential Orally disintegrating tablets...
Ideal choice when oncedaily dosing and minimal hepatic metabolism are desired (useful in hepatic impairment or polypharmacy with hepatically metabolis...
1. ECG is nonnegotiable: Always obtain baseline ECG and repeat after each dose escalation. QT prolongation risk is dosedependent and potentially fatal...
XR formulation allows oncedaily dosing but must be swallowed whole and taken without food or with light meal only Sedation can be therapeutically us...
1. Biphasic doseresponse: Low doses (50–300 mg/day) preferentially block presynaptic D2 autoreceptors, enhancing dopamine release and targeting negati...
1. Lowest effective dose principle: Essential to minimise EPS and tardive dyskinesia risk — titrate slowly and maintain at minimum therapeutic dose 2...