RxIndia
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1. Never use as monotherapy: Bedaquiline must always be part of a multidrug DRTB regimen to prevent emergence of resistance. 2. QTc monitoring is non...
Always coadminister pyridoxine (vitamin B6) — 50–100 mg/day in adults, 1–2 mg/kg/day in children — this is mandatory, not optional Psychiatric scree...
1. QTc confirmation mandatory: Always document QTc <500 ms before starting delamanid; repeat ECG weekly for first month. 2. Never use as monotherapy:...
Visual monitoring is nonnegotiable: Baseline visual assessment (acuity + colour vision) is MANDATORY before starting ethambutol; monthly monitoring du...
GI intolerance is the most common reason for treatment interruption — administer with food and consider dosesplitting (twice daily) to improve tolerab...
1. GI tolerability is the major limiting factor — Start low, titrate slowly; administer with food and acidic beverages to reduce nausea and mask taste...
Prothionamide and ethionamide are interchangeable thioamides with similar efficacy and toxicity profiles — choose one; NEVER couse both GI intoleran...
1. Never monotherapy: Rifampicin must always be used in combination for TB and leprosy — monotherapy leads to rapid resistance development within week...