RxIndia
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1. Resistance is the major issue: Fluoroquinolone resistance in enteric pathogens exceeds 80% in many parts of India. NEVER use empirically for typhoi...
G6PD testing is mandatory before initiation — haemolysis in G6PDdeficient patients can be lifethreatening; do not assume normal status Never use dap...
1. Counsel patients proactively about metallic taste — it is harmless but often causes noncompliance if unexpected 2. Zero alcohol rule: Emphasise co...
Shorter courses are often adequate: Singledose therapy (1500 mg) is highly effective for giardiasis and trichomoniasis — avoid unnecessary prolonged c...
1. Prodrug mechanism: Prulifloxacin is an ester prodrug that is rapidly hydrolysed in the body to the active metabolite ulifloxacin; this improves ora...
FDCs preferred: Always use fixeddose combinations rather than individual drugs whenever possible — improves compliance, reduces dosing errors, and pre...
1. Compliance advantage: Singledose 2 g regimen offers superior compliance compared to 5–7 day metronidazole courses — Preferred in patients with adhe...