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1. Evening dosing advantage: Single evening dose provides 24hour coverage and minimises any residual daytime sedation; aligns with circadian histamine...
Secondgeneration preferred for chronic use: For allergic rhinitis and chronic urticaria, cetirizine, loratadine, or fexofenadine are preferred due to ...
1. Age restriction is critical: Absolutely contraindicated in children below 2 years due to risk of respiratory depression and fatal CNS toxicity — th...
1. Active metabolite advantage: Desloratadine is the active metabolite of loratadine with a longer halflife (~27 hours), allowing reliable oncedaily d...
1. Highly sedating — Not suitable for patients requiring alertness; always warn about driving and machinery operation. 2. Not for chronic insomnia — ...
1. Less sedating than firstgeneration antihistamines — Suitable for patients requiring alertness (students, drivers, machine operators). 2. Oncedaily...
Nonsedating advantage — fexofenadine is the least sedating among commonly used secondgeneration antihistamines; preferred for patients requiring alert...
Sedation as therapeutic effect: Choose hydroxyzine when sedation is desirable (nocturnal pruritus, preprocedure anxiety); avoid when daytime alertness...
1. Evening administration is preferred as it aligns with peak nocturnal histamine release and mitigates any residual sedation during waking hours. 2....