RxIndia
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1. Patient selection: Topical amorolfine is most effective for mild–moderate distallateral subungual onychomycosis involving <50% of nail plate; consi...
Caspofungin demonstrates fungicidal activity against Candida species but is only fungistatic against Aspergillus — hence reserved as salvage therapy f...
1. Firstline choice: Clotrimazole remains a firstline topical antifungal for superficial dermatophytoses and candidiasis in India due to established e...
1. CSF penetration: Fluconazole is the only azole with reliable CSF penetration (~70–80% of plasma levels) — drug of choice for cryptococcal meningiti...
Never use as monotherapy — flucytosine resistance develops rapidly within days when used alone; always combine with amphotericin B (for cryptococcal m...
1. Fatty meal is essential — bioavailability increases 2–3 fold when taken with fatty food; counsel every patient 2. Verify formulation type — micros...
Oral ketoconazole is no longer firstline for systemic fungal infections — reserve for cases where itraconazole, fluconazole, or amphotericin B are una...
Preferred echinocandin in hepatic impairment compared to caspofungin — does not require dose adjustment for hepatic dysfunction Renalsafe antifungal...
Delayedrelease tablets are now standard for neutropenic prophylaxis due to consistent bioavailability — avoid oral suspension if tablets or IV availab...