RxIndia
Loading clinical data...
Loading clinical data...
1. Better psychiatric tolerability than Levetiracetam: Consider Brivaracetam in patients who developed behavioural adverse effects (irritability, aggr...
1. Lower sedation than other benzodiazepines: Clobazam has less sedative effect compared to clonazepam or diazepam — preferred benzodiazepine for chro...
1. Oncedaily dosing is a major advantage over carbamazepine and oxcarbazepine for compliance 2. Slower titration in elderly and renally impaired pati...
1. Seizuretype specific: Ethosuximide is highly effective for typical absence seizures but completely ineffective for focal seizures, generalised toni...
Lacosamide has minimal hepatic enzyme induction/inhibition — advantageous for patients on multiple medications or with comorbidities requiring polypha...
1. Preferred AED in hepatic impairment — minimal hepatic metabolism makes levetiracetam ideal for patients with liver disease or those on multiple hep...
1. Crossreactivity warning: ~25–30% crosssensitivity with carbamazepine — avoid in patients with previous serious rash to carbamazepine 2. Hyponatrae...
1. Slow titration is key: Most psychiatric adverse effects (aggression, irritability) occur during rapid titration. Increase by 2 mg weekly at minimum...
1. Reserve for resourcelimited settings — phenobarbitone causes significant cognitive impairment with chronic use; newer AEDs (levetiracetam, lamotrig...
1. Nonlinear kinetics are critical — once serum levels exceed 10 μg/mL, small dose increases (even 25–30 mg) can cause disproportionate level rises an...
1. Slow initiation essential: Always titrate slowly over 7–10 days to avoid excessive sedation; patients often discontinue prematurely due to early si...
1. Not firstline therapy — Rufinamide is exclusively for adjunctive use in LennoxGastaut Syndrome after other AEDs have failed. 2. Food enhances abso...
Hepatotoxicity risk is highest in children <2 years on polytherapy — avoid unless no alternatives; monitor LFTs rigorously Mandatory pregnancy couns...
1. Stiripentol is not a standalone antiepileptic — efficacy in Dravet syndrome is established only as adjunct to clobazam plus valproate; do not use a...
1. Slow titration is essential: Cognitive side effects (wordfinding difficulty, memory problems) are doserelated and minimised with gradual titration ...
1. Specialistonly drug: All vigabatrin initiations must be referred to paediatric or adult neurology — do not initiate in general practice due to irre...