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1. Triplet therapy is standard for HEC: Aprepitant must be combined with a 5HT3 antagonist and dexamethasone — never use as monotherapy for CINV preve...
1. Longer halflife advantage: Granisetron has a longer halflife (~9 hours) than ondansetron (~4 hours), allowing effective oncedaily dosing and better...
Superior as prophylaxis for motion sickness; less effective once symptoms begin Preferred over dimenhydrinate for longer action and relatively lower...
1. Combine with dexamethasone for CINV — ondansetron alone is less effective for highly emetogenic chemotherapy; combination significantly improves co...
Prolonged action advantage: Single prechemotherapy dose provides both acute and delayed CINV protection; eliminates need for multiday dosing unlike on...