RxIndia
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Acarbose is most effective for isolated postprandial hyperglycaemia — not useful for fasting glucose correction; consider for patients with predominan...
Initiate at 100 mg in all patients; reserve 300 mg for younger, wellhydrated patients with preserved renal function (eGFR ≥60) who need additional gly...
Less CV/renal outcome data compared to alternatives — VERTIS CV showed noninferiority for MACE but not superiority; dapagliflozin and empagliflozin ha...
Glargine has a relatively peakless profile over ~24 hours; it addresses basal insulin needs but NOT postprandial glucose excursions — prandial insulin...
Always initiate at 0.6 mg/day regardless of indication — this is for GI tolerability, not therapeutic effect; do not skip this step Nausea is the mo...
1. Firstline agent for Type 2 DM — Continue metformin unless contraindicated when adding other agents; proven cardiovascular benefit (UKPDS); no weigh...
1. Timing is critical: Miglitol must be taken with the first bite of each meal; taking it before or after meals significantly reduces efficacy. 2. Hy...
Premixed 70/30 insulin requires consistent meal timing and carbohydrate intake — emphasise this during patient counselling; not suitable for patients ...
Repaglinide is ideal for patients with irregular meal patterns — flexible "dosewithmeal" approach allows skipping dose when meal is skipped, reducing ...
Not a firstline agent — Reserve for patients inadequately controlled on metformin or sulfonylurea, or those intolerant to firstline agents; pioglitazo...